Hypocomplementemic Urticarial Vasculitis is a
skin disorder characterized by fixed urticarial lesions that appear
histologically (study of the microscopic anatomy of cells and tissues
of plants and animals) as a vasculitis. Vasculitis is a diverse group
of disorders that can be characterized by inflammatory destruction of
blood vessels. In hypocomplementemic urticarial vasculitis, both
arteries and veins of the patient are affected.
Urticarial vasculitis is
the outbreak of erythematous wheals that apparently look like
urticaria; however, histologically show variations of leukocytoclastic
vasculitis. It can be further subdivided into hypocomplementemic
variants and normocomplementemic. The hypocomplementemic form is mostly
associated with systemic symptoms and is related to connective-tissue
syndrome. Women are more likely to be affected, as the male to female
ratio for urticarial vasculitis is 1:2.
are several symptoms of urticarial vasculitis, including hives,
breathing difficulty, chronic hypocomplementemia, joint pain,
arthritis, inflammation of uvea of the eye, episcleritis, recurrent
abdominal pain, venulitis of dermid, glomerulonephritis, blood in
urine, and sometimes, excess protein in urine.
Hypocomplementemic Urticarial Vasculitis Syndrome
Hypocomplementemic Urticarial Vasculitis syndrome or
HUVS is an uncommon skin problem related to Systemic Lupus
Erythematosus (SLE). It is considered to be an independent
immunological disease. HUVS is sometimes also refered to as McDuffie
syndrome, after the researcher who published the first description
about this disease.
The most obvious sign of HUVS is Chronic Urticarial Vasculitis with
harmonized deficiency of C1q antibody in the serum. In addition, many
other organs are also involved, sometimes with severe effects. The
diagnosis can be confirmed by a specialist who performs a skin biopsy.
If you are suffering from Hypocomplementemic Urticarial Vasculitis
Syndrome, you should identify and avoid physical or drug triggers.
Sometimes, intake of systematic antihistamines can be useful.
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